July 16, 20205 yr Update from the doc on the recent vaccine trials https://www.nothingbutthetruthmd.com/2020/07/71520-covid-19-update.html Immunogenicity of a Candidate SARS-CoV-2 Vaccine NEJM 7/14/20 The first clinical data of any of the vaccines being investigated was released yesterday. The mRNA vaccine being produced by Moderna completed a phase 1 dosing trial in 45 healthy individuals ages 18 - 55. This was an open label study involving three different doses, 25mcg, 100mcg, 250 mcg repeated at day 28. Three groups, each of 15 individuals received one of the dosage regimens. Each group exhibited production of antibodies, the levels of which were dose related. Each group exhibited a further rise in antibody level after the second dose which was again dose related. Solicited side effects - accept for erythema, only the 250 mcg dose elicited symptoms that were graded as severe (defined below) Fatigue - severe - defined as preventing adult living activities (ADL) 14.3% Fever - severe 39-40 C - 7.1% Chills - - severe- prevent ADL 21.4% Headache - severe - requiring narcotic 7.1% Myalgias - severe - preventing ADL 7.1% Nausea - severe - preventing ADL - 7.1% Erythema - severe - > 10 mm. both 100 mcg and 250 mcg doses caused 6.7% Swelling - severe - > 10 mm 6.7% There were a variety of unsolicited side effects that were not graded. A larger study involving the 25 mcg and 100 mcg doses in 600 individuals is ongoing. A larger efficacy trial is slated to begin 7/27/20 which will include 30,000 volunteers and should be completed by November. It is very encouraging that there was a 100% antibody response. It remains to be seen whether this antibody response will be protective. I have seen reports that suggest that early glimpses at the data, if promising, might lead to early "emergency compassionate use" of the vaccine. I think this would be very ill advised. By the end of this trial, only 15,000 individuals will have received the vaccine, 15,000 will have received the sham vaccine. Looking back at the debacle in 1955 with the Salk polio vaccine, it took, on average 10,236 doses to result in one permanent paralysis. The plan is to administer several 100 million doses. A great aftermarket reporting system must be in place to prevent such a recurrence and we should proceed prudently. There is a second mRNA vaccine under development with the same target and which should perform similarly. Hopefully this will provide additional treatments. Live safely Be Well
July 16, 20205 yr 21 hours ago, The_Omega said: How many children in the us have died from the coronavirus? 20x more have died from the flu. Schools are not taught by children. They are not run by children. Bus drivers, janitors, nurses, lunchroom staff. All not children. The parents of the children. Probably mostly not children.
July 16, 20205 yr https://www.washingtonpost.com/nation/2020/07/16/kemp-georgia-mask-mandates/ Idiot.
July 16, 20205 yr 11 minutes ago, JohnSnowsHair said: https://www.washingtonpost.com/nation/2020/07/16/kemp-georgia-mask-mandates/ Idiot. yep. Quote Georgia Republican Gov. Brian Kemp issued an executive order Wednesday night, which outright banned cities and counties in the state from issuing mask orders to help stop the spread of COVID-19. The move, despite neighboring states like Alabama requiring masks in public, voided mask mandates in 15 local jurisdictions in the Peach State where they had been implemented. repugs are so dumb. 15 hours ago, SPIDER-MAN said: He isn't fired. Technically (and thankfully) Trump can't fire him. Fauci can keep doing what he's doing, just the White House will now concoct schemes to make him look like a dope. Saw Pennsylvania is cutting back again. I never go out anyway, so this doesn't hurt me much. Luzerne County has had very small amounts of positive tests since we opened back up. https://www.wnep.com/article/news/health/coronavirus/governor-tom-wolf-coronavirus-targeted-mitigation/523-db005e1c-1253-4dc7-af30-312c933002ba Spoiler we live in the same county, loretta!
July 16, 20205 yr Republican govs to fed govt: "stop telling us what to do! Let us handle this in a way that makes sense for our situation!" Republican gov to localities: "do as we say or we'll force you to!"
July 16, 20205 yr 22 minutes ago, mr_hunt said: yep. repugs are so dumb. Hide contents we live in the same county, loretta! This line here.... "The move, despite neighboring states like Alabama requiring masks in public, voided mask mandates in 15 local jurisdictions in the Peach State where they had been implemented." ...basically reads as "Masks: So easy, even Alabama can do it."
July 16, 20205 yr amazing...and then you have folks in pa all pissed off because they can't go to the bars.
July 16, 20205 yr 3 minutes ago, mr_hunt said: amazing...and then you have folks in pa all pissed off because they can't go to the bars. Can't remember the last time I just went to a bar to drink. Occasionally I'll pull up a seat and have a drink if I'm waiting for a table on a date night but that's about it. Getting old with kids, saving me from the Rona.
July 16, 20205 yr Since March I've been to the grocery store. Other than going to the park once, that's been it. This is the first week I've started to feel a little stir crazy, but that probably has a lot to do with not drinking. 🍻
July 16, 20205 yr 8 minutes ago, rambo said: Can't remember the last time I just went to a bar to drink. Occasionally I'll pull up a seat and have a drink if I'm waiting for a table on a date night but that's about it. Getting old with kids, saving me from the Rona. I'm at the point now where going to the bar is more of an annoyance than anything. I'd rather just sit out on the deck with friends (or in the basement in the winter), have a few drinks and an edible, and not deal with other dewshy a-holes.
July 16, 20205 yr 10 minutes ago, rambo said: Can't remember the last time I just went to a bar to drink. Occasionally I'll pull up a seat and have a drink if I'm waiting for a table on a date night but that's about it. Getting old with kids, saving me from the Rona. same. it's definitely for 20-somethings and single people trying to get laid. most people are aholes...why would i want to be around them while i'm drinking...and especially while they're drinking.
July 16, 20205 yr Not good. We've officially entered the period where Trump is hiding life and death information from the public out of fear it will hurt his re-election. Welcome to the Banana Republic.
July 16, 20205 yr New Cases of COVID-19 Are Mostly in Republican-Led States For the most part, when Donald Trump ordered the states to reopen their economies, Republican governors said "How fast?" and Democratic governors said "No thank you." That difference is now becoming clear in the data. Among the states reporting the most new cases, eight of the top 10 are led by Republicans: In the list above, only California and North Carolina have Democratic governors. Worse yet for the GOP, three of the states in the top five, Florida, Arizona, and Georgia, are probably going to be major battlegrounds. It is very likely that more cases is going to mean more deaths in a few weeks. The Biden campaign ads pretty much write themselves (Hint: Trump ordered your spineless governor to reopen your state, which he did. Now people are dying here needlessly on account of Trump). It is important to realize what the problem here is for the President. Once that is clear, the solution is straightforward. The problem is that the media are reporting lots of new cases of COVID-19 everywhere. This makes Trump look bad. The obvious solution, at least to him, is to have them stop reporting this. To this end, the administration has ordered hospitals, effective immediately, to stop reporting data to the CDC and to report it to the Dept. of HHS instead. This provides a way to minimize the number of cases and deaths reported, simply by changing the numbers. It also sidelines the CDC and Dr. Anthony Fauci even more. Problem solved. Maybe. If HHS orders the numbers to be "improved," somebody at HHS has to actually sit at a computer and make changes. Leaks could happen, as they did in Florida when data scientist Rebekah Jones was ordered to falsify information on the dashboard she built. Of course, if leaks happen, the top priority of the administration will be to hire some plumbers to fix the leak. That worked out pretty well for Richard Nixon, so why not try again? (V)
July 16, 20205 yr 4 minutes ago, LeanMeanGM said: 14,000 new FL cases and the highest death toll so far with 156 Usually a two week lag with deaths so now is about the time to see them roll in
July 16, 20205 yr 3 minutes ago, DaEagles4Life said: Usually a two week lag with deaths so now is about the time to see them roll in Yup, problem is new cases haven’t been slowing down at all. And everything is still back logged so 7-10 day wait for results
July 16, 20205 yr 3 hours ago, paco said: This is another reason why we needed more testing from the jump. We have no idea if what we are seeing now indicates a new spike or just the result of more available testing. Going by deaths, it looks like we are trending up a tad but thankfully no where near where we were at in April\May..... yet it would be interesting to see a similar chart showing daily new cases...just to see the lag between the increase in cases & the increase in fatalities.
July 16, 20205 yr 8 minutes ago, DaEagles4Life said: Usually a two week lag with deaths so now is about the time to see them roll in It's already happening in Florida:
July 16, 20205 yr Florida's 5-day rolling average for deaths was in the 30's at the beginning of July. Now it's in the 90's.
July 16, 20205 yr In fairness to Trump, I don't think he really intended people to drink bleach. He was thinking more like this...
July 16, 20205 yr On 7/15/2020 at 8:45 AM, The_Omega said: How many children in the us have died from the coronavirus? 20x more have died from the flu. Incorrect. A total of 185 influenza-associated pediatric deaths occurring during the 2019-2020 season have been reported to CDC. LINK The flu season is over. I count 32 deaths <15 years old. LINK The number jumps to 189 <25 years old. Since February. Not even an entire year. COVID-19 is still active so these numbers continue to grow.
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