November 18, 20205 yr Addressing male sexual and reproductive health in the wake of COVID-19 outbreak https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355084/ Mask up or you might get ED and be even less able to satisfy a woman than you are now.
November 18, 20205 yr Samuel L Jackson delivering a powerful message to the people in these tough times. In spoilers because..... Samuel L. Jackson Spoiler
November 18, 20205 yr Pfizer and BioNTech say final analysis shows coronavirus vaccine is 95% effective with no safety concerns A final analysis of the Phase 3 trial of Pfizer's coronavirus vaccine shows it was 95% effective in preventing infections, even in older adults, and caused no serious safety concerns, the company said Wednesday. The company counted 170 cases of coronavirus infection among volunteers who took part in the trial. It said 162 infections were in people who got placebo, or plain saline shots, while eight cases were in participants who got the actual vaccine. That works out to an efficacy of 95%, Pfizer said. The data show Pfizer's initial claim of a better than 90% efficacy -- a claim that stunned and pleased health officials and vaccine developers last week -- holds up. "Efficacy was consistent across age, race and ethnicity demographics. The observed efficacy in adults over 65 years of age was over 94%," Pfizer and its German partner BioNTech said in a joint statement. "There were 10 severe cases of Covid-19 observed in the trial, with nine of the cases occurring in the placebo group and one in the BNT162b2 vaccinated group." BNT162b2 is the experimental name for the vaccine. An independent group has been keeping an eye on results and side-effects. "To date, the Data Monitoring Committee for the study has not reported any serious safety concerns related to the vaccine," the companies said. "The only Grade 3 (severe) solicited adverse event greater than or equal to 2% in frequency after the first or second dose was fatigue at 3.7% following dose 2," the companies said. Older adults tended to have fewer adverse events and those they had were milder. Pfizer will seek EUA 'within days' Pfizer said it will seek US Food and Drug Administration emergency use authorization "within days." "These data also will be submitted to other regulatory agencies around the world," Pfizer said. They plan to publish the data in a peer-reviewed scientific journal, as well. "The rapid protection this vaccine provides -- combined with its tolerability profile in all age groups studied so far -- should help make this vaccine an important tool to address the current pandemic," said Dr. Ugur Sahin, CEO and co-founder of BioNTech. Pfizer said on November 9 that interim data provided initial evidence the vaccine had an efficacy of more than 90%. That data was based on the first 94 cases of coronavirus infection among volunteers. The company said at the time it would need to count more cases of infection in the trial before it could consider the Phase 3 part of the trial finished and seek FDA authorization. The Phase 3 clinical trial of the vaccine began on July 27. Pfizer said of 43,661 volunteers enrolled, 41,135 have received a second dose of the vaccine or placebo. The FDA said it wanted at least two months of safety tracking on volunteers after they got their second shots. The companies also said they have tried to recruit a diverse pool of volunteers, to match more closely the groups most severely affected by the pandemic. "Approximately 42% of global participants and 30% of U.S. participants have racially and ethnically diverse backgrounds, and 41% of global and 45% of U.S. participants are 56-85 years of age," Pfizer said. The 150 clinical trials sites in United States, Germany, Turkey, South Africa, Brazil and Argentina will continue to collect information about efficacy and safety for two more years. 1.3 billion doses expected in 2021 "Based on current projections, the companies expect to produce globally up to 50 million vaccine doses in 2020 and up to 1.3 billion doses in 2021," they said. Pfizer has three US vaccine manufacturing sites in St. Louis, Kalamazoo, Michigan and Andover, Massachusetts, plus one in the Belgian city of Puurs. "BioNTech's German sites will also be leveraged for global supply," the companies said. Many states have expressed concern about the fragility of the Pfizer vaccine, which must be kept at minus 75 degrees Celsius, or minus 103 degrees Fahrenheit -- far below the capability of standard freezers. But the companies said their custom packaging would help. "Pfizer is confident in its vast experience, expertise and existing cold-chain infrastructure to distribute the vaccine around the world," they said. "The companies have developed specially designed, temperature-controlled thermal shippers utilizing dry ice to maintain temperature conditions of -70°C," they added. "They can be used be as temporary storage units for 15 days by refilling with dry ice. Each shipper contains a GPS-enabled thermal sensor to track the location and temperature of each vaccine shipment across their pre-set routes leveraging Pfizer's broad distribution network." Vaccine maker Moderna released interim efficacy data Monday showing its vaccine provided about 95% protection. Both Moderna's and Pfizer's vaccine use a new and relatively untested vaccine technology that employs genetic material called messenger RNA or mRNA. The mRNA encodes for a piece of the coronavirus's spike protein-- the structure it uses to attach to cells it attacks. When injected into people, it causes some cells to produce little pieces of this spike protein, which the immune system recognizes and develops antibodies and immune cells to attack. So when a vaccinated person is exposed to the real virus, the immune system is already primed to neutralize it quickly.
November 18, 20205 yr 14 hours ago, SPIDER-MAN said: It isn't heartless because these people asked for it. You can't ignore death very long if you invite him into your house. And it's almost laughable that these idiots thought they would get the same drugs Trump did at Walter Reed. Hell I'll say it right now: I pray Trump gets it again and isn't so lucky the second time. Guys....?
November 18, 20205 yr 10 minutes ago, Kz! said: lmao, look at this scumbag. Hopefully he'll catch COVID and die: Like you? like all those at Trump rallies? Or his other super-spreader events?
November 18, 20205 yr 24 minutes ago, Toastrel said: Like you? like all those at Trump rallies? Or his other super-spreader events? Quit deflecting just because you worship democrats. Bottom line is, the guy can't even follow his own rules and may have literally killed the elderly by going to this thing. I know you and dems like Newsome think the pandemic rules only matter when you feel like following them, but that's just not the way this works. You guys are murderers.
November 18, 20205 yr Quote Government in Action Indonesia has the highest death toll from COVID-19 in Southeast Asia, and officials there are getting creative with punishments in addition to fines for not complying with mask laws. Metro News reported on Nov. 11 that regional governments are forcing scofflaws to do pushups, pull weeds, clean riverbeds and dig graves for coronavirus victims. Coffeeshop owner Evani Jesselyn of Jakarta said she was given a choice of paying a fine or cleaning public toilets after she was caught not wearing a mask in her car. [Metro News, 11/11/2020] I think anti-maskers should be tasked for grave digging.
November 18, 20205 yr 5 minutes ago, Kz! said: Quit deflecting just because you worship democrats. Bottom line is, the guy can't even follow his own rules and may have literally killed the elderly by going to this thing. I know you and dems like Newsome think the pandemic rules only matter when you feel like following them, but that's just not the way this works. You guys are murderers. Ok for thee but not for me
November 18, 20205 yr 4 minutes ago, Toastrel said: I think anti-maskers should be tasked for grave digging. How about the anti-maskers and the people who flagrantly disregard pandemic rules for social outings? Looking at you, bud.
November 18, 20205 yr 8 minutes ago, Kz! said: Quit deflecting just because you worship democrats. Bottom line is, the guy can't even follow his own rules and may have literally killed the elderly by going to this thing. I know you and dems like Newsome think the pandemic rules only matter when you feel like following them, but that's just not the way this works. You guys are murderers. It's ok to murder elderly people if you're ALSO elderly. Duh.
November 18, 20205 yr 11 minutes ago, sameaglesfan said: I know this is a joke, but I'll give a plug to swedish dishcloths Kinda half sponge half towel, last up to a year. Made the switch at the beginning of lockdowns. Won't switch back after. Haven't used paper towels in months.
November 18, 20205 yr Welp 3 more people got the virus in my store and I had to find out on my own. And the corporate office is having a department meeting with 40 people in one room. What a effing nightmare of a company I work for with this sheet
November 18, 20205 yr 1 minute ago, Bwestbrook36 said: Welp 3 more people got the virus in my store and I had to find out on my own. And the corporate office is having a department meeting with 40 people in one room. What a effing nightmare of a company I work for with this sheet Wear an n95 mask. If you can't find one, I will mail you one. Seriously.
November 18, 20205 yr 9 minutes ago, Kz! said: How about the anti-maskers and the people who flagrantly disregard pandemic rules for social outings? Looking at you, bud. What rules did I disregard? Feel free to make up as many as you can, since you are unable to deal with facts.
November 18, 20205 yr 7 minutes ago, Bwestbrook36 said: Welp 3 more people got the virus in my store and I had to find out on my own. And the corporate office is having a department meeting with 40 people in one room. What a effing nightmare of a company I work for with this sheet Yeah man that sounds really bad I'm sorry. F those guys.
November 18, 20205 yr 1 minute ago, Toastrel said: What rules did I disregard? Feel free to make up as many as you can, since you are unable to deal with facts. How about when you made a social visit that just couldn't wait to your kid's house where you admitted multiple people gathered throughout the weekend? I mean, I get it, the rules are tough to follow and sometimes it's inconvenient. That doesn't mean you get to pause the pandemic to cater to your whims. You're literally killing people.
November 18, 20205 yr Just now, Kz! said: How about when you made a social visit that just couldn't wait to your kid's house where you admitted multiple people gathered throughout the weekend? I mean, I get it, the rules are tough to follow and sometimes it's inconvenient. That doesn't mean you get to pause the pandemic to cater to your whims. You're literally killing people. You mean the visit where my wife and I painted with my kids one day, in a house, wearing masks, socially distancing and on other days other people helped them? Again, what rules did we break? How are we spreading the virus again? Did both of your parents molest you? Is that what broke you? Or was it that they didn't care enough to molest you?
November 18, 20205 yr 1 minute ago, Toastrel said: You mean the visit where my wife and I painted with my kids one day, in a house, wearing masks, socially distancing and on other days other people helped them? Again, what rules did we break? How are we spreading the virus again? Did both of your parents molest you? Is that what broke you? Or was it that they didn't care enough to molest you? Uhh, you gathered with people who aren't in your immediate household. Don't really care if it is or isn't part of your state's specific requirements. Any scientist will tell you gathering indoors with those outside your immediate household is a big no no. Do you really need the government to tell you when it is or isn't OK to do irresponsible things that literally kill the elderly? Like if your state didn't have a mask mandate you'd start walking around without a mask? Is that what you're saying? Shame on you.
November 18, 20205 yr Just now, Kz! said: Uhh, you gathered with people who aren't in your immediate household. Don't really care if it is or isn't part of your state's specific requirements. Any scientist will tell you gathering indoors with those outside your immediate household is a big no no. Do you really need the government to tell you when it is or isn't OK to do irresponsible things that literally kill the elderly? Like if your state didn't have a mask mandate you'd start walking around without a mask? Is that what you're saying? Shame on you. Yes. My wife and I put OURSELVES and ONLY OURSELVES at risk to help paint the interior of a house. All we need to do is quarantine for two weeks, which we do anyway. The only shame I feel is that I keep addressing you as if you were not a troll so butt hurt you make Trump look manly.
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