October 27, 20205 yr 5 minutes ago, mr_hunt said: but did you view the nuance contextually? huh? did you? I did in the context of his general take on things
October 27, 20205 yr 20 minutes ago, DrPhilly said: Agree 100% I'm very happy to have a discussion now with anyone that is capable of viewing it contextually as you are doing above. I don't think any country has been perfect, far from it. Absolutely not. I do think it is fair to make some initial comparisons though by looking at the area under the curve of per capita cases in similar countries, eg German vs France
October 27, 20205 yr 4 minutes ago, DEagle7 said: Absolutely not. I do think it is fair to make some initial comparisons though by looking at the area under the curve of per capita cases in similar countries, eg German vs France We can do that but of course you'd need to also consider the strategy of managing that curve over time. When you say "cases" what do you mean? Are you talking about confirmed positive cases or something else?
October 27, 20205 yr 2 minutes ago, DrPhilly said: We can do that but of course you'd need to also consider the strategy of managing that curve over time. When you say "cases" what do you mean? Are you talking about confirmed positive cases or something else? Yes new confirmed. Not a perfect measurement at all, but I think it's the best we can do for now. A deep dive into excess deaths will be interesting at some point but I don't know if I fully trust that data yet.
October 27, 20205 yr 7 minutes ago, DEagle7 said: Yes new confirmed. Not a perfect measurement at all, but I think it's the best we can do for now. A deep dive into excess deaths will be interesting at some point but I don't know if I fully trust that data yet. We'd need to somehow try to normalize the testing strategies to be able to compare the results in per capita. In the US my understanding is that the testing is far from uniform on a state by state basis. On the other hand, Sweden mistakenly did very little testing at all until the June timeframe. That's why the confirmed cases numbers in Sweden jump dramatically in June yet at the same time all the rates for hospital admittance, deaths, etc. go in the opposite direction immediately thereafter. I would think most places will have quite varied test strategies as compared across time and with each other. In any case, I think excess deaths will end up being the best measurement but for sure it is too early to make final conclusions using those at this point in time. I think that metric will be the best single metric long term even though the others like the economy, general level of health, etc. should and will be factored in as well.
October 27, 20205 yr 1 minute ago, DrPhilly said: We'd need to somehow try to normalize the testing strategies to be able to compare the results in per capita. In the US my understanding is that the testing is far from uniform on a state by state basis. On the other hand, Sweden mistakenly did very little testing at all until the June timeframe. That's why the confirmed cases numbers in Sweden jump dramatically in June yet at the same time all the rates for hospital admittance, deaths, etc. go in the opposite direction immediately thereafter. I would think most places will have quite varied test strategies as compared across time and with each other. In any case, I think excess deaths will end up being the best measurement but for sure it is too early to make final conclusions using those at this point in time. I think that metric will be the best single metric long term even though the others like the economy, general level of health, etc. should and will be factored in as well. Agreed. I do think that the testing strategies will be more normalized during this second wave than the initial spike(s?) at least. Still far from perfect, but most places seem as if they've established at least moderately robust testing protocols at this point.
October 27, 20205 yr 20 minutes ago, DEagle7 said: Agreed. I do think that the testing strategies will be more normalized during this second wave than the initial spike(s?) at least. Still far from perfect, but most places seem as if they've established at least moderately robust testing protocols at this point. Yes I think so. Let's see what we can get out of that info.
October 28, 20205 yr Hey!! GREAT NEWS!!! https://endpts.com/eli-lilly-lines-up-a-blockbuster-deal-for-covid-19-antibody-right-after-it-failed-a-niaid-trial/ Money to be made folks!!
October 28, 20205 yr 35 minutes ago, Kz! said: Eh, study of only about 200 patients and while 80% sounds pretty bad that's not super abnormal the closer you get to the equator ( the control group they used was about 50% deficient but average estimates in southern Europe can be upwards of 60%, and 80% in northern Africa and ME). Hospitalized patients, darker skin patients, and obese patients are also at risk of Vitamin D deficiency so they'd have to match the patients by stay duration ethnicity and BMI as well to control for that factor which I don't see mentioned. Maybe something here but it would need a LOT more evidence to get excited about.
October 28, 20205 yr 2 minutes ago, DEagle7 said: Eh, study of only about 200 patients and while 80% sounds pretty bad that's not super abnormal the closer you get to the equator ( the control group they used was about 50% deficient but average estimates in southern Europe can be upwards of 60%, and 80% in northern Africa and ME). Hospitalized patients and obese patients are also at risk of Vitamin D deficiency so they'd have to match the patients by stay duration and BMI as well to control for that factor which I don't see mentioned. Maybe something here but it would need a LOT more evidence to get excited about. I take vitamin D per my doctor and he mentioned these studies. It's hard to say though, naturally people with vitamin D deficiencies would be less healthy in general I would think so is this a meaningless correlation?
October 28, 20205 yr 5 minutes ago, BirdsFanBill said: I take vitamin D per my doctor and he mentioned these studies. It's hard to say though, naturally people with vitamin D deficiencies would be less healthy in general I would think so is this a meaningless correlation? This is part of it but so is sun exposure diet variety and skin tone. It's also pretty common in general so establishing a correlation is more difficult. It's certainly not going to hurt and is generally good for your health so by all means, take the supplements.
October 28, 20205 yr 14 minutes ago, DEagle7 said: Eh, study of only about 200 patients and while 80% sounds pretty bad that's not super abnormal the closer you get to the equator ( the control group they used was about 50% deficient but average estimates in southern Europe can be upwards of 60%, and 80% in northern Africa and ME). Hospitalized patients and obese patients are also at risk of Vitamin D deficiency so they'd have to match the patients by stay duration and BMI as well to control for that factor which I don't see mentioned. Maybe something here but it would need a LOT more evidence to get excited about. And without a randomized trial on supplementation, it doesn't give us anything that's really actionable, just another risk factor to consider among other comorbidities.
October 28, 20205 yr 52 minutes ago, Toastrel said: Hey!! GREAT NEWS!!! https://endpts.com/eli-lilly-lines-up-a-blockbuster-deal-for-covid-19-antibody-right-after-it-failed-a-niaid-trial/ Money to be made folks!! Latest data coming in on convalescent plasma and moabs was pretty underwhelming. Same for remdesivir.
October 28, 20205 yr On 10/17/2020 at 1:04 PM, Green Dog said: Just saw 700 new cases at SUNY Oneonta. The president of the school resigned. Not a good time to be a college president
October 28, 20205 yr 4 minutes ago, we_gotta_believe said: And without a randomized trial on supplementation, it doesn't give us anything that's really actionable, just another risk factor to consider among other comorbidities. I mean studies like this aren't themselves bad. I think they didn't fully control for confounding factors but that's not always easy to do in smaller studies. Studies like these aren't actionable but maybe can guide future RCTs. But catchy headlines like "80% of COVID patients have Vitamin D deficiency" are kinda misleading.
October 28, 20205 yr Hard times are a test of character. So far, most of the US is failing. The responsible people, people who actively work to stop the spread of infection are hampered by the stupid at home, the stupid at work, the stupid in local, state and federal government and the stupid in other states and countries. Personally, I care enough about the people around me to want to lessen the spread of infection during a pandemic.
October 28, 20205 yr France expected to impose four-week national lockdown Emmanuel Macron reportedly planning move after record number of new Covid cases
October 28, 20205 yr 3 hours ago, DEagle7 said: I mean studies like this aren't themselves bad. I think they didn't fully control for confounding factors but that's not always easy to do in smaller studies. Studies like these aren't actionable but maybe can guide future RCTs. But catchy headlines like "80% of COVID patients have Vitamin D deficiency" are kinda misleading. While I agree I do think there's some sort of connection with low Vit D and sickness. I was low and took the D2 weekly for awhile pre-cancer. After treatment it recovered to normal levels and I just take a multi vitamin everyday.
October 28, 20205 yr Just now, DiPros said: While I agree I do think there's some sort of connection with low Vit D and sickness. I was low and took the D2 weekly for awhile pre-cancer. After treatment it recovered to normal levels and I just take a multi vitamin everyday. It's a bit of a chicken-and-the-egg situation. People in the hospital/chronically sick for extended time are at risk for Vitamin D deficiency. However normal Vitamin D production requires UV exposure and people with prolonged illnesses tend to stay inside more/cover up when outside etc. Cancer meds can definitely mess up normal metabolism too. Definitely worth supplementing regardless, but a causal relationship would be really tricky to establish given how prevalent and multifactorial it is.
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