December 30, 20205 yr 4 minutes ago, EaglesRocker97 said: I just read that that the new strain that cropped up in CO may actually be a second UK mutation. Neat. https://www.nature.com/articles/d41586-020-02544-6 A good write up of the original mutation and implications. A big thing we have in our advantage is that the part of the spike protein that most of the antibodies bind to doesn't seem to have mutated much yet, so we'll see. The spike protein relies on a very specific configuration in order to open cell membranes, so there's only so much mutation that can occur within it while still allowing the virus to infect cells which works in the vaccine's favor.
December 30, 20205 yr 41 minutes ago, downundermike said: At work, yes. And if you dealt with what I dealt with, you would be shocked its not daily. The residential and commercial glazing industry is more like an adult day care. These guys are a bunch of baby's. I glaze your mom in her residence on the reg, brah.
December 30, 20205 yr 1 hour ago, DEagle7 said: A big thing we have in our advantage is that the part of the spike protein that most of the antibodies bind to doesn't seem to have mutated much yet, so we'll see. The spike protein relies on a very specific configuration in order to open cell membranes, so there's only so much mutation that can occur within it while still allowing the virus to infect cells which works in the vaccine's favor. Thanks, I'll check out the article. My worry, though, would be that the spike protein will eventually—and at this rate, relatively quickly—mutate to a point where the vaccines are rendered ineffective or significantly less effective.
December 30, 20205 yr 43 minutes ago, EaglesRocker97 said: Thanks, I'll check out the article. My worry, though, would be that the spike protein will eventually—and at this rate, relatively quickly—mutate to a point where the vaccines are rendered ineffective or significantly less effective. The spike protein has mutated slightly. Just not the area that we believe most of the antibodies target. It is worth monitoring closely absolutely, but most articles I've read have been optimistic about vaccine efficacy against mutated strains.
December 30, 20205 yr 14 minutes ago, Alpha_TATEr said: also, hotter than ginger. yep and not even close
December 30, 20205 yr 2 hours ago, DEagle7 said: https://www.nature.com/articles/d41586-020-02544-6 A good write up of the original mutation and implications. A big thing we have in our advantage is that the part of the spike protein that most of the antibodies bind to doesn't seem to have mutated much yet, so we'll see. The spike protein relies on a very specific configuration in order to open cell membranes, so there's only so much mutation that can occur within it while still allowing the virus to infect cells which works in the vaccine's favor. I read an article today that was one LinkedIn - I forget the source now....but basically said the spikes have spikes now. There was a patient that that was carrying 17 mutations of the virus. They called the latest one B.1.1.7 for the 17th mutation. I think it’m might be the guy in Colorado? The doctors were saying they have never seen anything like it and it wasn’t what they would expect to see. It did not paint an optimistic picture of the vaccine efficacy. They’re saying that the newest mutation is 70% more contagious and the patients are sicker and its hitting younger people harder as well. I’m getting very worried that this vaccine will be an epic fail!
December 30, 20205 yr 7 minutes ago, DBW said: I read an article today that was one LinkedIn - I forget the source now....but basically said the spikes have spikes now. There was a patient that that was carrying 17 mutations of the virus. They called the latest one B.1.1.7 for the 17th mutation. I think it’m might be the guy in Colorado? The doctors were saying they have never seen anything like it and it wasn’t what they would expect to see. It did not paint an optimistic picture of the vaccine efficacy. They’re saying that the newest mutation is 70% more contagious and the patients are sicker and its hitting younger people harder as well. I’m getting very worried that this vaccine will be an epic fail! Yes I have read about the new UK strain potentially being more virulent due to a more "open" configuration, but let's see what the data shows before panicking. The spike protein itself can mutate all it wants but it will depend on the receptor binding domain of the protein, which is the area that most of the antibodies are formed against. I haven't read much about the CO strain but at least the UK strain seems to have left that area mostly untouched which is part of the reason for optimism.
December 30, 20205 yr 29 minutes ago, DEagle7 said: Yes I have read about the new UK strain potentially being more virulent due to a more "open" configuration, but let's see what the data shows before panicking. The spike protein itself can mutate all it wants but it will depend on the receptor binding domain of the protein, which is the area that most of the antibodies are formed against. I haven't read much about the CO strain but at least the UK strain seems to have left that area mostly untouched which is part of the reason for optimism. Doesn't matter exactly what the data shows, it will be used by democrats to impose more strict measures. You heard it here first!
December 30, 20205 yr Masks now recommended in Sweden when traveling on buses and subways during rush hour for everyone over the age of 15. That’s the first recommendation for the general public to use masks.
December 30, 20205 yr 2 minutes ago, DrPhilly said: Masks now recommended in Sweden when traveling on buses and subways during rush hour for everyone over the age of 15. That’s the first recommendation for the general public to use masks. I even wear a mask and so do my kids when we are outside. Too many people around here have it, and they will walk right up on you
December 30, 20205 yr 11 minutes ago, DrPhilly said: Masks now recommended in Sweden when traveling on buses and subways during rush hour for everyone over the age of 15. That’s the first recommendation for the general public to use masks. GD Democrats (Making fun of KZ...not you)
December 30, 20205 yr 16 minutes ago, Gannan said: I even wear a mask and so do my kids when we are outside. Too many people around here have it, and they will walk right up on you We (my family) has worn them in certain situations where we were in places that didn’t easily allow for distancing. Mostly we’ve been able to avoid being near others.
December 30, 20205 yr 1 hour ago, Kz! said: Doesn't matter exactly what the data shows, it will be used by democrats to impose more strict measures. You heard it here first! You mean like wolf did today? Oh wait, he lifted restrictions. Typical Republican you are, making up lies and believing in them so much that you have yourself fooled.
December 30, 20205 yr Just now, DBW said: You mean like wolf did today? Oh wait, he lifted restrictions. Typical Republican you are, making up lies and believing in them so much that you have yourself fooled. What restrictions were lifted?
December 30, 20205 yr 2 minutes ago, DBW said: You mean like wolf did today? Oh wait, he lifted restrictions. Typical Republican you are, making up lies and believing in them so much that you have yourself fooled. You’ll see.
December 30, 20205 yr 7 minutes ago, DrPhilly said: What restrictions were lifted? All of the recent ones: indoor dining is allowed, groups of 25 or more inside allowed, gyms open, bars open, no 14 day quarantine when entering state, etc. to clarify when I say lifted I mean the current restrictions will expire on Jan 4th as scheduled.
December 30, 20205 yr 6 minutes ago, Toty said: Does Elin Grindemyr still live up there? I still have a hard time believing she even exists. I would worship her feet like a pantheon of nordic gods wait... forget I said that I looked her up. Says she is living back in her hometown. She’s 37 now. Don’t worry though. There are plenty of young 20 somethings here that look just like that. Head on over and we can take a gander.
December 30, 20205 yr 1 minute ago, Toty said: 37 is just fine. I have nieces over 20 now and it's getting in that creepy range. Not that I'd turn it down (the 20 year olds, not the nieces). Man I need to learn how to edit. 37 is more than fine 😁 You can still casually read the menu though. No need to try to place an order.
December 30, 20205 yr 2 hours ago, DBW said: I read an article today that was one LinkedIn - I forget the source now....but basically said the spikes have spikes now. There was a patient that that was carrying 17 mutations of the virus. They called the latest one B.1.1.7 for the 17th mutation. I think it’m might be the guy in Colorado? The doctors were saying they have never seen anything like it and it wasn’t what they would expect to see. It did not paint an optimistic picture of the vaccine efficacy. They’re saying that the newest mutation is 70% more contagious and the patients are sicker and its hitting younger people harder as well. I’m getting very worried that this vaccine will be an epic fail! You're like the joe shades of covid vaccines. The only way the vaccine will fail is if there's a string of adverse reactions to it and too many people freak out and stop getting vaccinated.
December 31, 20205 yr 4 hours ago, Kz! said: Doesn't matter exactly what the data shows, it will be used by democrats to impose more strict measures. You heard it here first! I mean the data suggests the new virus could be more virulent (spike protein is "open" more than "closed" compared to baseline) so it is kind of a big deal. I was only talking about how it pertains to the vaccine.
December 31, 20205 yr 3 hours ago, we_gotta_believe said: You're like the joe shades of covid vaccines. The only way the vaccine will fail is if there's a string of adverse reactions to it and too many people freak out and stop getting vaccinated. 😂 thats harsh I mean, I’m not ignoring the science and I’m sure they are doing what they can and we should believe in it, but there’s an element of unknown that you can’t ignore. You can’t say "ah they have this vaccine development stuff all figured out” because if that were the case we wouldn’t ever have a new virus to deal with, we’d just have superhuman immune systems and get our bulletproof shots at birth and never worry about our health again. The virus is moving the goal posts and they (the docs and virologists and the cdc etc) admittedly did not expect to see the mutations they did. Now you want me to blindly believe that the magic potion they developed in record time is going to be the virus killer and stop it on its tracks? If you wanna believe the science of medicine then you have to believe the science of virus mutations and the fact that the virus could be smarter than the "experts” in the medical community.
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